13th Annual Course

13^th Course on the BBB in CNS Drug Development
online

Principles, Transport Kinetics, Methods & Translation to humans

23, 24, 29, 30, 31 January 2024, on-line

Following the previously successful ones, the 13th Annual Course on the BBB in CNS Drug Development is organized in 2024 as a 5 half-days on-line course! It has a new schedule and significantly updated and expanded content, covering both small drug molecules and biologics.

Below you can find all relevant information on the program and registration

The Program

DAY I: Tuesday Jan 23rd

Basic Aspects of the Blood-Brain Barrier and Pharmacokinetic Principles

15.00 – 15.30	Welcome, introduction
15.30 – 16.00	BBB Morphology, Anatomy, Physiology and Function
16.00 – 16.10	10 min break
16.10 -17.10	Mechanism of BBB transport intrabrain distribution
17.10 – 17.40	30 min break
17.40 – 18.40	BBB transport and intrabrain distribution: Rate and extent. Impact on brain vs plasma PK, including PK principles
18.40 – 19.00	Summing up and discussion of Day I

DAY II: Wednesday Jan 24th

Experimental methods/approaches for investigating BBB transport and intra-brain distribution

15.00 – 15.15	Introduction to today's theme
15.15 – 15.35	In vitro methods (cell cultures)
15.35 – 15.55	In situ methods (brain sampling techniques)
15.55 – 16.05	10 min break
16.05 – 16.25	In vivo monitoring methods: CSF & microdialysis
16.25 – 16.40	In vivo monitoring methods: PET, CT, MRI
16.40 – 17.10	30 min break
17.10 – 18.10	Combinatory Mapping Approach to determine distribution of drugs between different brain sites
18.10 – 18.40	Hands-on exercise: BBB and intra-brain factors for obtaining target site concentrations
18.40 – 19.00	Summing up and discussion of Day II

DAY III: Monday Jan 29th

Computational Methods to Investigate and Predict BBB Transport and Intra-brain Distribution

15.00 – 15.15	Introduction to today's theme
15.15 – 16.10	Hands-on exercise: impact of variability in rate and/or extent of transport on target site concentrations
16.10 – 16.20	Lunch
16.20 – 16.40	In silico methods
16.40 – 17.10	CNS PBPK modeling approaches
17.10 -17.40	Applications of CNS PBPK modeling predictions (LEICNSPK3.0)
17.40 – 18.10	30 min break
18.10 – 18.40	Sources of variability in CNS drug distribution
18.40 – 19.00	Summing up and discussion of Day III

DAY IV: Tuesday Jan 30th

Approaches to Improve CNS Target Site Delivery

15.00 – 15.15	Introduction to today's theme
15.15 – 15.30	Use of active transporters for efflux and influx
15.30 – 15.40	Invasive methods for CNS target site delivery
15.40 – 15.50	Focused ultra-sound
15.50 – 16.00	10 min break
16.00 – 17.00	Use of receptor-mediated transport for large molecules
17.00 – 17.30	30 min break
17.30 – 18.00	Nanocarriers as a field with promise
18.00 – 18.40	Hands-on exercise: Shiny App – CNS PBPK model – Part 1 – animals
18.40 – 19.00	Summing up and discussion of Day IV

DAY IV: Wednesday Jan 31st

Integration and Translation (to human) of CNS Drug Delivery Principles

15.00 – 15.15	Introduction on integration and translation of CNS drug delivery principles
15.15 – 16.00	Translational PK and PKPD relationships of CNS active drugs
16.00 – 16.10	10 min break
16.10 – 17.10	Hands-on exercise: Shiny App – CNS PBPK model – Part 2 – animal to human translation
17.10 – 17.40	30 min break
17.40 – 18.10	Overall perspectives
18.10 – 18.40	Discussions on learning experience and final questions
18.40	End of course

Evaluations from the previous BBB course

I found the course to be very valuable for my present work: Average 9.1/10
I would very much like to recommend this course to colleagues: Average 9.5/10

Fee

The course fee includes course attendance and course material.

Early payment:

PhD students*	€ 1595,- (excl. VAT)
Academic	€ 1795,- (excl. VAT)
Business	€ 1995,- (excl. VAT)

Regular pricing:

PhD students*	€ 1895,- (excl. VAT)
Academic	€ 2095,- (excl. VAT)
Business	€ 2295,- (excl. VAT)

Registration Form

Please register by filling out the form below. A specified invoice can be made upon request. Registration is complete upon receiving the payment. A confirmation of payment and therewith registration will be sent by email

Payment information

Udenaes Consulting
SEB (106 40 Stockholm, Sweden)
1) Pay directly to bank account
IBAN Account SE3850000000053681044384
BIC: ESSESESS
2) Pay via PayPal

3) Please ask by email for an invoice, specify participant and funding unit

Cancellation policy

In case of cancellation before December 22nd 2023 payment will be restituted (-10% administration costs). In case of cancellation after December 22nd 2023 there will be no restitution, but the participant may be exchanged for another participant.

Courses on the BBB in CNS Drug Development